Targeting hernia operations using sustainable resources and green nanotechnologies. An integrated PanEuropean approach

Overview

Hernia operations are among the most common surgical procedures performed today with over 20 million cases annually worldwide. Hernia incidents are associated with pain and poor quality-of-life for the patient and lead to enormous healthcare costs, exceeding US $48 billion in the US annually. At present, hernia operations rely heavily on non-degradable polypropylene, polytetrafluoroethylene and nylon meshes. However, these polymers are often associated with foreign body reaction; implant failure; and hernia reoccurrence (over 42%). Moreover, leaking chemicals of these polymers are often deleterious to the surrounding cells and tissue and immobilise post-operative drug treatments. In addition, the process technologies are often associated with environmental risks. Herein, we propose a novel approach that employs recent advances in green nanotechnology and sustainable raw materials for scaffold fabrication that not only will eliminate toxic chemicals from the processes, but will also enhance functional repair due to superior biological properties. Specifically, we aim to fabricate a nano-fibrous mesh with well-defined nano-topography using cellulose; human recombinant collagen, derived from transgenic tobacco plants; and biodegradable polylactic/polyglycolic acid as raw materials. The green credentials of this innovative approach lie in the use of sustainable eco-friendly raw materials that will produce biodegradable waste products and therefore replacing hazardous chemicals currently in use. Thus, this proposal directly fits the call for the substitution of materials or components with ‘green nano-technology’.

Indicative Outputs

An academic, clinical and industrial update on electrospun, additive manufactured and imprinted medical devices. Ryan CN, Fuller KP, Larrañaga A, Biggs M, Bayon Y, Sarasua JR, Pandit A, Zeugolis DI. Expert Review of Medical Devices, Vol. 12, No. 5, pp. 601-612, 2015. PubMed

To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Delgado LM, Bayon Y, Pandit A, Zeugolis DI. Tissue Engineering Part B: Reviews, Vol. 21, No. 3, pp. 298-313, 2015. PubMed

Influence of sterilisation methods on collagen-based devices stability and properties. Delgado LM, Pandit A, Zeugolis DI. Expert Review of Medical Devices, Vol. 11, No. 3, pp. 305-314, 2014. PubMed

Surface hierarchical porosity in poly (ε-caprolactone) membranes with potential applications in tissue engineering prepared by foaming in supercritical carbon dioxide. Pintado-Sierra M, Delgado L, Aranaz I, Marcos-Fernandez A, Reinecke H, Gallardo A, Zeugolis D, Elvira C. The Journal of Supercritical Fluids, Vol. 95, pp. 273-284, 2014. ScienceDirect

The multifaceted potential of electro-spinning in regenerative medicine. Fuller K, Pandit A, Zeugolis DI. Pharmaceutical Nanotechnology. Vol. 2, No. 1, pp. 23-34, 2014. Bentham Science

Partners

Funding Agencies